30 Powerful Bible Quotes About Depression (With Commentary)

Depression can be a deeply painful and isolating experience. The Bible speaks to the emotional struggles we face, offering comfort, hope, and encouragement in times of despair. These scriptures remind us that God is close to those who are brokenhearted and that He offers healing and peace. Let these verses be a reminder of God’s love, His presence in our pain, and His promise to provide comfort and restoration in our darkest moments.

Psalm 34:18 – “The Lord is close to the brokenhearted and saves those who are crushed in spirit.”

This verse assures those who are grieving or struggling with depression that God is near. He understands our pain and is actively involved in comforting us. It encourages us to draw near to God in our sorrow, trusting that He will provide the healing we need. This scripture reminds us that God’s presence brings peace and that He is intimately involved in restoring our broken hearts, offering us His compassion and love in our pain.

Matthew 11:28 – “Come to me, all you who are weary and burdened, and I will give you rest.”

This verse is an invitation from Jesus to bring our burdens to Him, especially when we are feeling overwhelmed or depressed. Jesus promises to provide rest and peace for those who are weary. It encourages us to trust in His ability to lift our burdens and find true relief in His presence. This scripture reminds us that, when life feels heavy, Jesus offers rest, comfort, and renewal for our souls.

2 Corinthians 1:3-4 – “Praise be to the God and Father of our Lord Jesus Christ, the Father of compassion and the God of all comfort, who comforts us in all our troubles, so that we can comfort those in any trouble with the comfort we ourselves receive from God.”

This verse speaks of God as the ultimate source of comfort in times of grief and distress. It motivates believers to not only receive God’s comfort but to also share it with others who are suffering. It reminds us that God’s comfort is abundant and has a purpose—to help us minister to others in their pain. This scripture shows us that God’s presence is deeply personal and transformative in times of emotional pain.

Psalm 42:11 – “Why, my soul, are you downcast? Why so disturbed within me? Put your hope in God, for I will yet praise him, my Savior and my God.”

This verse speaks to the emotional turmoil we may experience during times of depression, urging us to put our hope in God. It encourages believers to speak truth to their souls, despite their feelings of despair. The psalmist chooses to praise God even in sorrow, demonstrating that hope and faith in God can lead us to praise, even in dark times. This scripture reminds us that God is our source of hope, even when we feel overwhelmed by sadness.

Isaiah 41:10 – “So do not fear, for I am with you; do not be dismayed, for I am your God. I will strengthen you and help you; I will uphold you with my righteous right hand.”

This verse offers reassurance to those experiencing depression, reminding them that God is always with them. It encourages believers not to fear, as God promises to strengthen and support them. This scripture motivates us to rely on God’s power to help us overcome feelings of hopelessness and fear. It reminds us that we do not have to face life’s challenges alone—God is our constant source of strength and help in our moments of weakness.

1 Peter 5:7 – “Cast all your anxiety on him because he cares for you.”

This verse invites believers to release their worries and burdens to God, knowing that He cares deeply for them. It encourages us to trust that God is not only aware of our struggles but is willing to take them from us. This scripture motivates us to surrender our anxiety, depression, and pain to God, knowing that He will carry us through. It reminds us that God’s love and care are sufficient to handle our emotional and mental burdens.

Psalm 73:26 – “My flesh and my heart may fail, but God is the strength of my heart and my portion forever.”

This verse speaks to the weakness we may experience during times of depression, assuring us that God is the true strength of our hearts. Even when our emotions fail us, God remains our constant source of strength and stability. It motivates us to trust in God’s ability to sustain us when we feel emotionally depleted. This scripture reminds us that God is always there to uphold and strengthen us, even in our moments of deepest struggle.

2 Samuel 22:7 – “In my distress I called to the Lord; I called out to my God. From his temple he heard my voice; my cry came to his ears.”

This verse reflects the psalmist’s cry for help during a time of distress. It encourages us to bring our deepest struggles, including depression, to God, trusting that He hears and responds to our cries. This scripture motivates us to seek God in times of emotional pain, knowing that He listens and is faithful to provide comfort and deliverance. It reminds us that God’s attention and care are constant, even in our darkest moments.

John 14:1 – “Do not let your hearts be troubled. You believe in God; believe also in me.”

This verse encourages believers to place their trust in Jesus when they are experiencing emotional turmoil. It motivates us to focus on our faith in God, which provides peace in the midst of distress. Jesus assures us that, even when life is overwhelming, we can find comfort in trusting in Him. This scripture reminds us that our faith in God is the key to overcoming troubled hearts, as He offers peace and hope in times of despair.

2 Corinthians 12:9 – “But he said to me, ‘My grace is sufficient for you, for my power is made perfect in weakness.’ Therefore I will boast all the more gladly of my weaknesses, so that the power of Christ may rest upon me.”

This verse speaks of God’s grace in our moments of weakness, including when we face depression. It encourages us to rely on God’s grace, which is sufficient to meet our needs and sustain us. This scripture motivates us to embrace our weaknesses, knowing that they are an opportunity for God’s power to be displayed. It reminds us that God’s grace is enough to help us endure and find strength, even in the midst of emotional and mental struggles.

Matthew 5:4 – “Blessed are those who mourn, for they will be comforted.”

This verse speaks to those who are grieving or struggling with depression, offering the promise of God’s comfort. It assures believers that mourning is not without hope, and that God will bring comfort to those in sorrow. It motivates us to hold on to the promise of God’s presence in our pain, knowing that He will comfort and heal us. This scripture reminds us that mourning and grief, though difficult, are not the end, and God’s comfort will bring healing.

Psalm 56:8 – “You keep track of all my sorrows. You have collected all my tears in your bottle. You have recorded each one in your book.”

This verse speaks to God’s deep compassion for those who are grieving or depressed, assuring them that He sees every tear and every sorrow. It motivates us to find comfort in the fact that God cares about our emotional pain and is actively present in our grief. This scripture reminds us that we are never alone in our sorrow, and God collects our tears, offering His care and compassion to bring healing to our broken hearts.

Lamentations 3:22-23 – “Because of the Lord’s great love we are not consumed, for his compassions never fail. They are new every morning; great is your faithfulness.”

This verse offers hope to those struggling with depression, reminding them of God’s unending love and compassion. It encourages us to trust that God’s mercy is renewed daily, providing the strength we need to face each new day. This scripture motivates us to rely on God’s faithfulness, even when we feel overwhelmed by sadness or despair. It reminds us that God’s love and compassion are constant, and He is always ready to renew us in our moments of weakness.

Romans 8:18 – “I consider that our present sufferings are not worth comparing with the glory that will be revealed in us.”

This verse offers comfort to those struggling with depression, encouraging them to look beyond their current pain. It reminds believers that suffering is temporary, and the future glory that awaits is far greater. It motivates us to endure through hardships with hope, knowing that God will eventually bring restoration. This scripture reassures us that, while life may feel overwhelming at times, the joy and peace of God’s promises far outweigh our present struggles.

Isaiah 40:29 – “He gives strength to the weary and increases the power of the weak.”

This verse speaks directly to those feeling emotionally drained or defeated by depression. It encourages us to rely on God for strength and renewal, knowing that He will empower us when we feel weak. This scripture motivates believers to trust in God’s ability to provide the emotional energy and resilience needed to persevere. It reminds us that, no matter how exhausted we feel, God is always there to strengthen and support us in our weakness.

Psalm 9:9 – “The Lord is a refuge for the oppressed, a stronghold in times of trouble.”

This verse speaks of God as a place of safety and security for those experiencing emotional pain or depression. It motivates believers to seek refuge in God when they feel overwhelmed by sorrow or despair. This scripture reminds us that God is not distant from our suffering but is a stronghold where we can find peace, comfort, and protection. It assures us that in God’s presence, we are secure and supported during our darkest moments.

1 Peter 5:10 – “And the God of all grace, who called you to his eternal glory in Christ, after you have suffered a little while, will himself restore you and make you strong, firm and steadfast.”

This verse offers hope to those experiencing depression or difficult trials, reassuring them that God will restore them. It encourages believers to persevere, knowing that after a season of suffering, God will bring healing and strength. This scripture motivates us to trust in God’s process of restoration, which will ultimately make us stronger and more resilient. It reminds us that even in the depths of depression, God’s plan for our lives includes healing and spiritual growth.

1 Thessalonians 5:11 – “Therefore encourage one another and build each other up, just as in fact you are doing.”

This verse speaks to the importance of community and encouragement in times of struggle. It motivates believers to support one another, especially those experiencing depression or emotional pain. By uplifting and comforting each other, we can bring light to those who are suffering. This scripture reminds us that we are not meant to go through life alone and that encouraging others, especially in their lowest points, is an expression of God’s love and care.

Hebrews 4:15-16 – “For we do not have a high priest who is unable to empathize with our weaknesses, but we have one who has been tempted in every way, just as we are—yet he did not sin. Let us then approach God’s throne of grace with confidence, so that we may receive mercy and find grace to help us in our time of need.”

This verse assures believers that Jesus understands our struggles and emotional pain, including depression. He has experienced the depths of human suffering and can empathize with our pain. It encourages us to confidently approach God, knowing He offers mercy and grace in our times of need. This scripture reminds us that Jesus is not distant from our sorrow but has walked through suffering to bring us the grace and healing we need in our darkest moments.

Matthew 11:29 – “Take my yoke upon you and learn from me, for I am gentle and humble in heart, and you will find rest for your souls.”

This verse offers comfort to those feeling burdened by depression or anxiety, inviting them to find rest in Christ. It encourages believers to surrender their emotional struggles to Jesus, who offers peace and relief. This scripture motivates us to trust in Christ’s gentle and humble nature, knowing that He will carry our burdens with us and give us rest for our souls. It reminds us that true rest comes from following Jesus and relying on His grace.

2 Corinthians 4:8-9 – “We are hard pressed on every side, but not crushed; perplexed, but not in despair; persecuted, but not abandoned; struck down, but not destroyed.”

This verse acknowledges the reality of emotional pain, feeling overwhelmed, or experiencing depression, yet it offers hope. It reminds believers that while life’s trials may be intense, they do not define or destroy us. It motivates us to persevere through difficulties, knowing that God is with us, even in our lowest moments. This scripture assures us that although we may experience suffering, we are never abandoned, and God’s strength will enable us to endure and overcome.

Isaiah 61:3 – “And provide for those who grieve in Zion—to bestow on them a crown of beauty instead of ashes, the oil of joy instead of mourning, and a garment of praise instead of a spirit of despair. They will be called oaks of righteousness, a planting of the Lord for the display of his splendor.”

This verse speaks of God’s promise to replace despair with joy and beauty. It encourages believers to trust in God’s ability to bring restoration and healing to their emotional wounds. It motivates us to look forward to God’s transformative work in our lives, knowing that He will replace our mourning with joy and our sadness with praise. This scripture reminds us that even in the midst of depression, God can bring healing and cause us to shine with His righteousness.

Romans 8:37 – “No, in all these things we are more than conquerors through him who loved us.”

This verse offers encouragement to those struggling with depression, reminding them that, through Christ, they can overcome anything. It motivates believers to recognize their victory over despair and depression, not because of their strength but because of Christ’s love and power. This scripture reminds us that no matter how difficult our struggles may be, we are empowered by God’s love to triumph over them and emerge stronger through His grace.

Psalm 40:1-3 – “I waited patiently for the Lord; he turned to me and heard my cry. He lifted me out of the slimy pit, out of the mud and mire; he set my feet on a rock and gave me a firm place to stand. He put a new song in my mouth, a hymn of praise to our God.”

This verse speaks of God’s deliverance from emotional despair, lifting us from the depths of sorrow and placing us on solid ground. It encourages believers to wait on God patiently, trusting that He will hear their cries and bring healing. This scripture motivates us to turn to God in our grief, knowing that He will lift us up, restore our joy, and give us a new song to sing in praise of His goodness.

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