30 Bible Verses For Depression And Hopelessness (With Commentary)

Depression and hopelessness are profound challenges that many individuals face, impacting mental, emotional, and spiritual well-being. In times of darkness, the Bible offers words of comfort, encouragement, and hope. In this compilation, we explore 30 “Bible Verses for Depression and Hopelessness,” accompanied by commentary, aiming to provide solace and a reminder of the enduring hope found in God’s Word.


  1. Psalm 34:17-18

    “When the righteous cry for help, the Lord hears and delivers them out of all their troubles. The Lord is near to the brokenhearted and saves the crushed in spirit.”

    Commentary: God’s attentive ear and nearness offer solace and deliverance to the brokenhearted, assuring that cries for help are not in vain.

  2. Psalm 42:11

    “Why are you cast down, O my soul, and why are you in turmoil within me? Hope in God; for I shall again praise him, my salvation and my God.”

    Commentary: The psalmist acknowledges inner turmoil but redirects the soul toward hope in God, anticipating a return to praise and acknowledgment of divine salvation.

  3. Isaiah 41:10

    “Fear not, for I am with you; be not dismayed, for I am your God; I will strengthen you, I will help you, I will uphold you with my righteous right hand.”

    Commentary: God’s reassurance promises strength, help, and support, dispelling fear and dismay.

  4. Psalm 23:4

    “Even though I walk through the valley of the shadow of death, I will fear no evil, for you are with me; your rod and your staff, they comfort me.”

    Commentary: In the midst of darkness, the presence of God brings comfort and dispels fear, guiding and protecting like a shepherd’s rod and staff.

  5. Matthew 11:28-30

    “Come to me, all who labor and are heavy laden, and I will give you rest. Take my yoke upon you, and learn from me, for I am gentle and lowly in heart, and you will find rest for your souls. For my yoke is easy, and my burden is light.”

    Commentary: Jesus invites those burdened by life’s struggles to find rest and ease in Him, learning from His gentle and humble nature.

  6. Psalm 30:5

    “For his anger is but for a moment, and his favor is for a lifetime. Weeping may tarry for the night, but joy comes with the morning.”

    Commentary: God’s enduring favor surpasses momentary troubles, promising a shift from weeping to joy in due time.

  7. Philippians 4:6-7

    “Do not be anxious about anything, but in everything by prayer and supplication with thanksgiving let your requests be made known to God. And the peace of God, which surpasses all understanding, will guard your hearts and your minds in Christ Jesus.”

    Commentary: The prescription for anxiety lies in prayer, thanksgiving, and presenting requests to God, resulting in a transcendent peace that guards hearts and minds.

  8. 2 Corinthians 1:3-4

    “Blessed be the God and Father of our Lord Jesus Christ, the Father of mercies and God of all comfort, who comforts us in all our affliction, so that we may be able to comfort those who are in any affliction, with the comfort with which we ourselves are comforted by God.”

    Commentary: God, the source of comfort, invites believers to extend the same comfort to others, creating a cycle of solace.

  9. Psalm 55:22

    “Cast your burden on the Lord, and he will sustain you; he will never permit the righteous to be moved.”

    Commentary: Entrusting burdens to God ensures sustenance and steadfastness, reinforcing the security of the righteous.

  10. Psalm 139:23-24

    “Search me, O God, and know my heart! Try me and know my thoughts! And see if there be any grievous way in me, and lead me in the way everlasting!”

    Commentary: A plea for self-examination and divine guidance, acknowledging God’s omniscience and seeking the path of everlasting life.

  11. Romans 8:38-39

    “For I am sure that neither death nor life, nor angels nor rulers, nor things present nor things to come, nor powers, nor height nor depth, nor anything else in all creation, will be able to separate us from the love of God in Christ Jesus our Lord.”

    Commentary: The unwavering love of God, regardless of circumstances, stands as an impenetrable force against separation.

  12. Psalm 56:3-4

    “When I am afraid, I put my trust in you. In God, whose word I praise, in God I trust; I shall not be afraid. What can flesh do to me?”

    Commentary: Trust in God dismantles fear, emphasizing the futility of human efforts against divine protection.

  13. Psalm 121:1-2

    “I lift up my eyes to the hills. From where does my help come? My help comes from the Lord, who made heaven and earth.”

    Commentary: Looking beyond earthly troubles to the Creator, this psalm celebrates divine help and sustenance.

  14. John 14:27

    “Peace I leave with you; my peace I give to you. Not as the world gives do I give to you. Let not your hearts be troubled, neither let them be afraid.”

    Commentary: Jesus bequeaths a peace that transcends worldly understanding, urging believers to resist troubled and fearful hearts.

  15. Psalm 121:7-8

    “The Lord will keep you from all evil; he will keep your life. The Lord will keep your going out and your coming in from this time forth and forevermore.”

    Commentary: God’s comprehensive protection encompasses life and every aspect of daily existence, extending throughout eternity.

    Read : Genesis 1 (With Commentary and Explanation)

  16. Jeremiah 29:11

    “For I know the plans I have for you, declares the Lord, plans for welfare and not for evil, to give you a future and a hope.”

    Commentary: God’s plans for believers are characterized by welfare, a future, and hope, dispelling despair and uncertainty.

  17. Psalm 37:23-24

    “The steps of a man are established by the Lord when he delights in his way; though he fall, he shall not be cast headlong, for the Lord upholds his hand.”

    Commentary: Delighting in God’s ways ensures the establishment of one’s steps and the assurance of divine support, even in moments of stumbling.

  18. Isaiah 26:3

    “You keep him in perfect peace whose mind is stayed on you because he trusts in you.”

    Commentary: Trusting in God and fixing one’s mind on Him leads to perfect peace, regardless of external circumstances.

  19. Psalm 37:4-5

    “Delight yourself in the Lord, and he will give you the desires of your heart. Commit your way to the Lord; trust in him, and he will act.”

    Commentary: Finding joy in the Lord, entrusting one’s path to Him, and placing trust in His actions yield fulfillment and answered desires.

  20. Matthew 6:25-27

    “Therefore I tell you, do not be anxious about your life, what you will eat or what you will drink, nor about your body, what you will put on. Is not life more than food, and the body more than clothing? Look at the birds of the air: they neither sow nor reap nor gather into barns, and yet your heavenly Father feeds them. Are you not of more value than they?”

    Commentary: Jesus encourages a shift away from anxiety, highlighting God’s care for the smallest creatures as evidence of His greater concern for humanity.

  21. 1 Peter 5:6-7

    “Humble yourselves, therefore, under the mighty hand of God so that at the proper time he may exalt you, casting all your anxieties on him, because he cares for you.”

    Commentary: Humility, combined with casting anxieties on God, leads to His exaltation and the assurance of His caring nature.

  22. Psalm 40:1-3

    “I waited patiently for the Lord; he inclined to me and heard my cry. He drew me up from the pit of destruction, out of the miry bog, and set my feet upon a rock, making my steps secure. He put a new song in my mouth, a song of praise to our God. Many will see and fear, and put their trust in the Lord.”

    Commentary: Patient waiting on the Lord results in divine rescue, stability, and the testimony of God’s faithfulness.

  23. Matthew 11:28-29

    “Come to me, all who labor and are heavy laden, and I will give you rest. Take my yoke upon you, and learn from me, for I am gentle and lowly in heart, and you will find rest for your souls.”

    Commentary: Jesus extends an invitation to those burdened, offering rest and the opportunity to learn from His gentle and humble character.

  24. Psalm 37:7

    “Be still before the Lord and wait patiently for him; fret not yourself over the one who prospers in his way, over the man who carries out evil devices!”

    Commentary: Stillness and patience in waiting on the Lord counteract anxiety, preventing distress over the apparent success of evildoers.

  25. Isaiah 43:1-2

    “But now thus says the Lord, he who created you, O Jacob, he who formed you, O Israel: ‘Fear not, for I have redeemed you; I have called you by name, you are mine. When you pass through the waters, I will be with you; and through the rivers, they shall not overwhelm you; when you walk through fire you shall not be burned, and the flame shall not consume you.'”

    Commentary: God’s personal redemption and protective presence reassure believers facing trials, promising resilience against overwhelming challenges.

  26. John 16:33

    “I have said these things to you, that in me you may have peace. In the world, you will have tribulation. But take heart; I have overcome the world.”

    Commentary: Jesus’ acknowledgment of worldly tribulations is accompanied by the assurance of peace derived from His victorious overcoming of the world.

  27. Romans 15:13

    “May the God of hope fill you with all joy and peace in believing, so that by the power of the Holy Spirit you may abound in hope.”

    Commentary: God, the source of hope, grants believers joy, peace, and abundant hope through the indwelling power of the Holy Spirit.

  28. Lamentations 3:22-23

    “The steadfast love of the Lord never ceases; his mercies never come to an end; they are new every morning; great is your faithfulness.”

    Commentary: God’s enduring love and mercies, renewed daily, exemplify His unwavering faithfulness.

  29. 2 Corinthians 4:16-18

    “So we do not lose heart. Though our outer self is wasting away, our inner self is being renewed day by day. For this light momentary affliction is preparing for us an eternal weight of glory beyond all comparison, as we look not to the things that are seen but to the things that are unseen. For the things that are seen are transient, but the things that are unseen are eternal.”

    Commentary: Believers are encouraged to focus on the eternal perspective, recognizing the transient nature of present challenges in light of the glory awaiting them.

  30. Psalm 27:1

    “The Lord is my light and my salvation; whom shall I fear? The Lord is the stronghold of my life; of whom shall I be afraid?”

    Commentary: Acknowledging God as light, salvation, and stronghold dispels fear and fosters trust in His protective presence.


May these “Bible Verses for Depression and Hopelessness” and their commentaries serve as a source of comfort, encouragement, and renewed hope for those navigating challenging seasons. May the transformative power of God’s Word bring light and healing to the depths of the soul, guiding individuals toward enduring hope found in Christ.

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