30 Powerful Best Bible Verses For A Depression (With Commentary)

Depression can be a heavy burden to carry, but God’s Word provides a source of hope, strength, and comfort. Through Scripture, God speaks directly into our pain and sorrow, reminding us that we are not alone and that He is with us in every season of life. These 30 Bible verses are meant to provide encouragement, peace, and reassurance for those struggling with depression, pointing us toward the hope we have in Christ and the comfort found in God’s presence.

Bible Verses For A Depression

1. Psalm 34:18
“The Lord is close to the brokenhearted and saves those who are crushed in spirit.”

This verse reminds us that God is always near when we are at our lowest. For those battling depression, this promise provides comfort, knowing that God is especially close to those who are brokenhearted. He is not distant; He actively seeks to save, comfort, and uplift us in our darkest moments.

2. Isaiah 41:10
“So do not fear, for I am with you; do not be dismayed, for I am your God. I will strengthen you and help you; I will uphold you with my righteous right hand.”

In moments of deep despair, God reassures us that we do not need to be afraid or discouraged. His presence brings strength and support. When depression leaves us feeling weak, God promises to uphold us with His strength and never let us fall. He is always with us, even when we feel alone.

3. Matthew 11:28
“Come to me, all you who are weary and burdened, and I will give you rest.”

Jesus invites those who are tired, overwhelmed, and burdened to come to Him. In depression, rest can feel elusive, but Christ offers a peace that refreshes our soul. This verse encourages us to lay our burdens at Jesus’ feet, trusting that He will provide the rest and relief we desperately need.

4. Psalm 42:11
“Why, my soul, are you downcast? Why so disturbed within me? Put your hope in God, for I will yet praise him, my Savior and my God.”

This verse expresses the inner turmoil that often comes with depression, but it also points to hope. Despite feeling downcast, the psalmist encourages us to put our trust in God. Even when our emotions overwhelm us, we are reminded that God is still worthy of praise and that He will lift us up.

5. 1 Peter 5:7
“Cast all your anxiety on him because he cares for you.”

Depression often brings anxiety and worry. This verse is an invitation to hand all our concerns over to God. It reassures us that God cares deeply about our struggles and wants to carry our burdens for us. His loving care is a constant reminder that we don’t have to bear our pain alone.

6. Psalm 23:4
“Even though I walk through the darkest valley, I will fear no evil, for you are with me; your rod and your staff, they comfort me.”

This well-known verse brings comfort to those going through the darkest valleys of life, such as depression. It reassures us that God walks with us through our suffering, protecting and guiding us. We are never alone in our darkest moments because God’s presence is always there to comfort and lead us.

7. Isaiah 40:31
“But those who hope in the Lord will renew their strength. They will soar on wings like eagles; they will run and not grow weary, they will walk and not be faint.”

Depression can drain us of energy and hope, but this verse promises that when we place our hope in the Lord, He will renew our strength. God gives us the power to keep going, even when we feel weary. He lifts us up and helps us rise above our circumstances.

8. Philippians 4:6-7
“Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your requests to God. And the peace of God, which transcends all understanding, will guard your hearts and your minds in Christ Jesus.”

This passage teaches us to bring all our worries to God in prayer. In return, God promises us His peace—peace that is beyond human understanding and that will guard our hearts and minds. In times of depression, God’s peace can be a powerful source of comfort and protection against anxious thoughts.

9. Psalm 55:22
“Cast your cares on the Lord and he will sustain you; he will never let the righteous be shaken.”

This verse is a reminder that when we cast our cares and worries on God, He sustains us. Even when depression threatens to overwhelm us, God promises that He will not let us fall. His sustaining power is always available to carry us through even the toughest moments.

10. Romans 8:38-39
“For I am convinced that neither death nor life, neither angels nor demons, neither the present nor the future, nor any powers, neither height nor depth, nor anything else in all creation, will be able to separate us from the love of God that is in Christ Jesus our Lord.”

This powerful verse reminds us that nothing—absolutely nothing—can separate us from God’s love. In times of depression, when we might feel unloved or alone, we can cling to the truth that God’s love is constant, unbreakable, and eternal. His love remains, even in our darkest moments.

11. Lamentations 3:22-23
“Because of the Lord’s great love we are not consumed, for his compassions never fail. They are new every morning; great is your faithfulness.”

Even when life feels overwhelming, this verse reminds us that God’s love and compassion never fail. Each day brings new mercies and fresh strength from God. His faithfulness is a constant source of hope, and He will never let us be consumed by our struggles.

12. 2 Corinthians 12:9
“But he said to me, ‘My grace is sufficient for you, for my power is made perfect in weakness.’ Therefore I will boast all the more gladly about my weaknesses, so that Christ’s power may rest on me.”

This verse teaches us that God’s grace is enough for us, even when we feel weak and broken. In our moments of weakness, God’s power shines the brightest. When depression leaves us feeling powerless, we can find strength in knowing that God’s grace will sustain us and carry us through.

13. Joshua 1:9
“Have I not commanded you? Be strong and courageous. Do not be afraid; do not be discouraged, for the Lord your God will be with you wherever you go.”

This verse is a command to be strong and courageous, but it is also a promise that God will be with us wherever we go. In times of depression, when fear and discouragement feel overwhelming, we can take courage in knowing that God’s presence is with us every step of the way.

14. Psalm 46:1
“God is our refuge and strength, an ever-present help in trouble.”

When depression feels like a storm, this verse reassures us that God is our refuge and strength. He is always present, ready to help us in times of trouble. We can run to Him for protection and strength, knowing that He will provide the help and support we need to endure.

15. Romans 15:13
“May the God of hope fill you with all joy and peace as you trust in him, so that you may overflow with hope by the power of the Holy Spirit.”

This verse speaks of the hope, joy, and peace that come from trusting in God. When depression threatens to rob us of these things, we can trust that the Holy Spirit will fill us with hope and peace, helping us to overcome despair and overflow with the hope that comes from God.

16. John 16:33
“I have told you these things, so that in me you may have peace. In this world you will have trouble. But take heart! I have overcome the world.”

Jesus acknowledges the difficulties we face in this world but offers us His peace. In the midst of depression, we can take heart, knowing that Jesus has already overcome the world. His victory over sin, death, and suffering means that we can find peace and hope in Him, even in hard times.

17. 1 Thessalonians 5:16-18
“Rejoice always, pray continually, give thanks in all circumstances; for this is God’s will for you in Christ Jesus.”

This passage encourages us to find reasons for gratitude and joy, even in difficult circumstances. Depression can make it hard to feel joyful, but by maintaining a spirit of prayer and thankfulness, we can find strength and peace. God’s will for us includes joy, even when life feels overwhelming.

18. Psalm 9:9
“The Lord is a refuge for the oppressed, a stronghold in times of trouble.”

For those who feel oppressed by depression, this verse reminds us that God is our refuge and stronghold. He offers safety and protection in times of trouble. When we feel overwhelmed by life’s challenges, we can take comfort in knowing that God is our fortress, shielding us from harm.

19. Philippians 4:13
“I can do all this through him who gives me strength.”

This verse reminds us that with God’s strength, we can face any challenge, including depression. God gives us the power to endure and overcome, providing us with the strength we need to persevere. No matter how difficult life becomes, God’s strength is always available to us.

20. Isaiah 26:3
“You will keep in perfect peace those whose minds are steadfast, because they trust in you.”

This verse promises perfect peace for those who keep their minds focused on God. In the midst of depression, when peace feels distant, we can find rest in God by trusting Him. His peace is steady and reliable, calming our hearts and minds as we rely on His presence.

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